Novel antiosteoporotic supplements against estrogen deprived rats ab 87.9 € als Taschenbuch: Antiosteoporotic activities of Cicer arietinum seed and Coelatura aegyptiaca shell. Aus dem Bereich: Bücher, Wissenschaft, Biologie,
Novel antiosteoporotic supplements against estrogen deprived rats ab 87.9 EURO Antiosteoporotic activities of Cicer arietinum seed and Coelatura aegyptiaca shell
Liver is one of the vital organ endow with several important homeostatic responsibilities in the body. One of the primary functions of the liver is to aid in the metabolism of ingested substances including food, dietary supplements, fluids and majority of medicines. The complications arise with liver affects the entire system of the body. Thus there is an essential need of the medications for the treatment of liver diseases devoid of other adverse effects. Herbal Therapy is one of the best therapies used in medical practices since ancient times with lesser unfavorable effects. In the western world, as the people are becoming aware of the potency and side effect of synthetic drugs, there is an increasing interest in the natural product remedies. Today estimate that about 80% of people in developing countries still relays on traditional medicine based largely on species of plants and animals for their primary health care. Thus these two herbs Foeniculum vulgare and Thymus Vulgaris were selected for the evaluation of hepatoprotective activity against antitubercular drug induced hepatotoxicity in rats.
Supplementation of omega-3 fatty acids is very effective in reducing oxidative stress through the improvement of antioxidant enzymes activities . Fish and flaxseed oils are nutritional supplements have a high concentration of omega-3 fatty acids.Flax seed oil is rich in alpha linolenic acid (ALA) while fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study we aimed to compare the effects of flaxseed and fish oils in reducing oxidative stress especially in attenuating DNA damage through the evaluation of urinary 8-hydroxyguanosine (8-OHdG) in experimental diabetes. The main finding in our study was the reduction of urinary isoprostanes and 8-OHdH , in addition to the reduction of insulin resistance during diabetes. In conclusion, flaxseed and fish oils administration has a potential effect on decreasing insulin resistance in diabetic rats through the scavenging of free radicals and increasing superoxide dismutase . This study also concluded that ,fish oil was more effective than flaxseed oil.
Recent advances in the neurobiology of Aging explains the role of nutritional supplements in the modulation of brain physiology,morphology, and vascular development and suggested new ways of drug administration in disease and health in particular to the aging society. Nutritional supplements alters with the signalling of neurotransmitters in the central nervous system in particular, the Cholinergic and the dopaminergic pathways which primarily controls voluntary and involuntary physiological actions.In this piece of work,I did evaluate the role of Alpha lipoic acid (thioctic acid), Posiphen supplementation in a model of cerebrovascular injury administered in the aged rats and transgenic mice models. The bioavailability of tizanidine(Sirdalaud) was used as a good model in evaluating intra nasal route of administration as an alternative route especially in the aging group with swallowing difficulties.
Aluminium is the most abundant metal known for its neurotoxicity in humans. It has been reported to be involved in the etiology of several neurodegenerative diseases like Alzheimer's disease. This book provides the effectiveness of nitric oxide synthase inhibitors in modulating the toxicity induced by aluminum injections in rats on the biochemical, behavioral and morphological changes. Pretreatment with nitric oxide synthase inhibitors prevented the behavioural deficits induced by aluminium, meaning that they may prevent learning and memory deficits on this model of Alzheimer's disease. Results of this book should help in understanding the protective effects of nitric oxide synthase inhibitors against the cellular damage caused by aluminium-induced oxidative stress. Book will also show that nitric oxide synthase inhibitors are worthy of investigation as a potential supplements in the treatment of neurological disorders, in which case oxidative stress effects are minimized.
The present investigation was aimed to elucidate the toxic effects of selenium on male reproductive organs in albino rats by injecting sub lethal and lower doses of selenium intraperitoneally. The higher doses of selenium caused slight hypotrophy of testes and significantly decreased weights and the secretory activities of male accessory reproductive structures in male albino rats indicating that selenium might interfere with the androgen action at the target sites. It is suggested that interaction of selenium with receptor protein may change the configuration of receptor proteins, thereby decreasing the steroid binding affinity and possibly altering the way in which the receptor can interact with other cellular molecules, thus altering androgen action at the target sites. The study reveals that both low and high selenium concentrations have negative influence on reproductive performance. So dietary supplements should be used judiciously (staying well below the toxic level) and exposure to selenium should be minimized.
Phytoestrogens are found in fruits, vegetables, grains and nuts and most abundant in soybeans. Phytoestrogen intake as food or dietary supplements, in particular soya products has been increased because of their pivotal role in prevention and treatment of hormone-dependent cancers, cardiovascular diseases, osteoporosis, and age-related diseases. According to the report published by the United Soybean Board in 2009, 84% of US consumers perceive soy as healthy diet and 32% deliberately consume soy products at least once in a month. Dietary consumption of phytoestrogens is a matter of considerable concern in humans. Exposure to exogenous estrogenic chemicals such as phytoestrogens may have detrimental effects on male reproductive health and fertility. We have evaluated systematically and presented the data in this book whether chronic exposure to low doses of genistein and diadzein has any significant effect on reproduction in adult male Wistar rats. Since fetuses and infants are exposed to phytoestrogens through breast milk, soy-based infant formula, this book also provides valuable information on effect of exposure to genistein and diadzein during embryonic period on reproduction.
Osteoporosis is a socio-economic problem that requiring appropriate management strategies to modulate the bone turnover disorder. Estrogen replacement therapy and bisphosphonate drugs are effective for both prevention and therapy of osteoporosis, but recent findings have shown that their long term administration are not safe. Thereby natural alternative treatments are urgently needed. Therefore, the present study selected Cicer arietinum seed extract as a phytoestrogen source and/or Coelatura aegyptiaca shell powder as a calcium source to evaluate their effectiveness against osteoporosis induced by ovariectomy.